An Open Label, Multi-center Clinical Trial of Topical 5% Minoxidil Solution for the Treatment of Male Androgenetic Alopecia (A Phase IV Study).
- Author:
Hwa Young PARK
1
;
Won Soo LEE
;
Jangkyu PARK
;
Do Won KIM
;
Seok Yong AHN
;
Ye Jin JUNG
;
Byung In RO
;
Woo Young SIM
;
Sung Wook PARK
;
Gwang Seong CHOI
;
Hyung Ok KIM
;
Chang Hun HUH
;
Tae Young YOON
;
Moon Bum KIM
;
Ki Ho KIM
;
Haejun SONG
;
Sook Jung YUN
Author Information
1. Department of Dermatology, Yonsei University Wonju College of Medicine, Korea. leewonsoo@yonsei.ac.kr
- Publication Type:Clinical Trial ; Multicenter Study ; Original Article
- Keywords:
Androgenetic alopecia;
5% minoxidil
- MeSH:
Alopecia;
Hair;
Humans;
Male;
Minoxidil;
Republic of Korea;
Research Personnel;
Scalp
- From:Korean Journal of Dermatology
2009;47(3):295-302
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Topical 5% minoxidil solution stimulates new hair growth and it helps stop the loss of hair on individuals with androgenetic alopecia (AGA). OBJECTIVE: We wanted to assess the efficacy and safety of topical 5% minoxidil solution for treating Korean men with AGA. METHODS: This was a 24-week, open label, clinical trial that was conducted at 14 university dermatologic centers nationwide throughout South Korea as a multicenter study of the Korean Hair Research Society. The eligible subjects for this study were 18- to 65 year-old men with androgenetic alopecia, as defined by the Norwood scale as type III vertex, IV and IVA. A total of 175 men (20~62 years old) with AGA applied topical 5% minoxidil solution twice daily. Efficacy was evaluated by 1) the total hair count per 1 cm2 and 2) the mean hair diameter and 3) the patient assessment and 4) the investigator assessment of the change in scalp coverage and the benefit of treatment. RESULTS: At week 24 as compared with baseline, there was a statistically significant increase in the total hair counts and the mean hair diameter (p<.0001). Topical 5% minoxidil solution helped improve the investigator and patient assessments. The topical 5% minoxidil solution was well tolerated over a 24-week period. CONCLUSION: We believe that topical 5% minoxidil solution is a safe and effective drug for Korean men with AGA.
