Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome Caused by Topical Ophthalmic Use of Dorzolamide.
- Author:
Jae Wang KIM
1
;
Sang Yop SHIN
Author Information
1. Department of Dermatology, Jeju National University School of Medicine, Jeju, Korea. rulid@cheju.ac.kr
- Publication Type:Case Report
- Keywords:
Dorzolamide;
Stevens-johnson syndrome;
Toxic epidermal necrolysis
- MeSH:
Absorption;
Acetazolamide;
Asian Continental Ancestry Group;
Carbonic Anhydrases;
Epidermal Necrolysis, Toxic;
Humans;
Hypersensitivity;
Methazolamide;
Stevens-Johnson Syndrome;
Sulfonamides;
Thiophenes
- From:Korean Journal of Dermatology
2009;47(3):317-321
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the potentially life-threatening, acute hypersensitivity reaction to inciting drugs. These diseases have been often associated with systemic carbonic anhydrase inhibitor such as acetazolamide or methazolamide in Korean and Japanese patients. Dorzolamide is a recently developed topical carbonic anhydrase inhibitor with few significant systemic adverse effects. To the best of our knowledge, there have been only a few reports of SJS or TEN caused by topical dorzolamide in the literature. We herein present two cases of TEN and one case of SJS related with topical use of dorzolamide. It should be emphasized that although rarely, topical dorzolamide may cause serious sulfonamide hypersensitivity such as SJS or TEN in the susceptible patient through the systemic absorption.
