Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection
- Author:
Jiang CONGSHAN
1
,
2
,
3
;
Li XIAOWEI
;
Ge CHANGRONG
;
Ding YUANYUAN
;
Zhang TAO
;
Cao SHUAI
;
Meng LIESU
;
Lu SHEMIN
Author Information
1. Institute of Molecular and Translational Medicine (IMTM)
2. Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center,76 West Yanta Road,Xi'an,Shaanxi,710061,PR China
3. Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University),Ministry of Education,Xi'an,Shaanxi,710061,PR China
- Keywords:
SARS-CoV-2;
Virus variation;
Nucleic acid detection;
Asymptomatic infection
- From:
Journal of Pharmaceutical Analysis
2021;11(3):257-264
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year.With the expanding second wave of the pandemic in winter,the continuous evolution of SARS-CoV-2 has brought new issues,including the significance of virus mutations in infection and the detection of asymptomatic infection.In this review,we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19,primarily focusing on their strengths and limitations.We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection.The review finally sum-marized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.
