Drug treatment of laryngeal granuloma after hypothermic plasma radiofrequency surgery for early glottic carcinoma
10.3760/cma.j.cn115455-20210609-00767
- VernacularTitle:早期声门型喉癌低温等离子射频术后喉肉芽肿的药物治疗
- Author:
Cuiping SHE
1
;
Qingfeng ZHANG
;
Delong LIU
;
Mengsi JIAO
;
Yuqi SHI
Author Information
1. 大连市中心医院耳鼻咽喉头颈外科 116033
- Keywords:
Laryngealneoplasms;
Granuloma, laryngeal;
Plasma radiofrequency;
Drug treatment;
Zinc agent
- From:
Chinese Journal of Postgraduates of Medicine
2021;44(12):1091-1095
- CountryChina
- Language:Chinese
-
Abstract:
Objective:to investigate the efficacy of drugs in the treatment of laryngeal granuloma after hypothermic plasma radiofrequency surgery in early glottic carcinoma.Methods:Thirty-two cases of laryngeal granulomacoming from 289 patients with early glottic carcinoma treated by plasma radiofrequency surgery under endoscope-supported laryngoscopefrom January 2011 to January 2021 in Dalian Municipal Central Hospital were enrolled. All patients were given oral treatment of zinc gluconate tablets (70 grams per tablet, containing 10 grams of zinc). The usage was 3 tablets each time, twice a day. If the granulation was located in the vocal cord, 20 mg of esomeprazolec was added twice a day, and taken orally on an empty stomach. The total course of treatment was 6-12 weeks.Results:Follow-up and reexamination of electronic laryngoscope showed that the granulation of all patients began to become smaller after 3 weeks of drug treatment and gradually disappeared after 6-12 weeks. After the granulation disappeared, the drug was stopped, and there was no recurrence.Two patients developed nausea and epigastric discomfort after oral administration of zinc gluconate tablets for 3 weeks, and the discomfort disappeared after reducing the dose.Conclusions:Oral administration of zinc gluconate tablets alone or in combination with esomeprazoleis an effective, safe and low recurrence method for laryngeal granuloma after hypothermic plasma radiofrequency ablation in early glottic carcinoma.
