Clinical efficacy and safety of stent placement combined with drug therapy and drug therapy alone in patients with vertebral artery stenosis
10.3760/cma.j.cn115455-20201218-01830
- VernacularTitle:椎动脉起始部狭窄患者支架置入联合药物治疗与单纯药物治疗的临床疗效及安全性分析
- Author:
Qiping ZHANG
1
;
Yuying LI
;
Haining LI
;
Bingsong LIANG
;
Yuan RAO
;
Xiaoling CHEN
;
Jian LI
;
Yingdao CHEN
Author Information
1. 广西壮族自治区梧州市工人医院神经内科 543001
- Keywords:
Vertebrobasilar insufficiency;
Stents;
Drug therapy;
Comparative effectiveness research
- From:
Chinese Journal of Postgraduates of Medicine
2021;44(10):898-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical efficacy and safety of stent implantation combined with drug therapy and drug therapy alone in patients with vertebral artery initial stenosis.Methods:A total of 112 patients with vertebral artery initial stenosis who were treated in Wuzhou Workers′ Hospital from January 2016 to June 2018 were selected and divided into drug group and stent + drug group according to random number table method, with 56 patients in each group. The drug group received drug therapy alone, and stent + drug group received stent implantation combined with drug therapy. The incidence of ischemic events in posterior circulation, the improvement of vascular stenosis rate and the improvement of neurological function injury were observed in the two groups after 12 months of treatment.Results:The success rate in the stent + drug group was 100.0%(56/56). The rate of vascular stenosis in the stent + drug group was lower than that in the drug group: (15.21 ± 3.74)% vs. (18.62 ± 4.27)% ; but the incidence of restenosis was higher than that in the drug group:26.79%(15/56) vs. 7.14%(4/56), the differences were statistically significant ( P<0.05). The total incidence of ischemic events in the posterior circulation after treatment in the stent + drug group was lower than that in the drug group: 8.93%(5/56) vs. 28.57%(16/56), and the difference was statistically significant ( χ2 = 7.092, P = 0.008). After treatment, the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS) in the stent + drug group were lower than those in the drug group: (2.30 ± 0.36) scores vs. (3.75 ± 0.52) scores, (4.11 ± 0.51) scores vs.(6.14 ± 0.57) scores, and the differences were statistically significant ( P<0.05). Conclusions:The application of stent implantation combined with drug regimen in the treatment of patients with vertebral artery initial stenosis can effectively reduce the neurological damage of patients, andimprove the total effective rate, which is conductive to the improvement of patients′ quality of life, but the rate of stent restenosis is high.
