Diagnosis value of multiparametric magnetic resonance imaging in prostate cancer and its relationship with clinicopathological grade
10.3760/cma.j.cn115455-20201116-01597
- VernacularTitle:多参数磁共振成像诊断前列腺癌的价值及其与临床病理分级的关系
- Author:
Degang YE
1
Author Information
1. 河北省秦皇岛市第二医院医学影像科 066600
- Keywords:
Prostatic neoplasms;
Magnetic resonance imaging;
Diagnosis, differential;
Gleason score
- From:
Chinese Journal of Postgraduates of Medicine
2021;44(9):832-837
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the diagnosis value of multiparametric magnetic resonance imaging (mpMRI) in prostate cancer, and its relationship with clinicopathological grade.Methods:The clinical data of 50 patients with prostate cancer and 50 patients with benign prostatic hyperplasia from January to May 2019 in Qinhuangdao Second Hospital were retrospectively analyzed. All patients were examined by mpMRI, and the results were assessed by 2 radiologists according to the prostate imaging reporting and data system version 2 (PI-RADS 2). The mpMRI results were compared with Gleason score (GS). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of mpMRI for prostate cancer.Results:For single sequence of mpMRI, when the cut-off value of DWI sequence was higher than 2 scores, the area under the curve (AUC) in diagnosis of prostate cancer was 0.951, and the sensitivity and specificity were 94.00% and 88.00%, respectively; when the cut-off value of T 2WI sequence was higher than 3 scores, the AUC in diagnosis of prostate cancer was 0.920, and the sensitivity and specificity were 80.00% and 96.00%, respectively; when DEE was positive, the AUC in diagnosis of prostate cancer was 0.810, and the sensitivity and specificity were 94.00% and 68.00%, respectively; when the 3 indexes were combined to diagnose prostate cancer, the AUC was 0.960, and the sensitivity and specificity were 90.00% and 96.00%, respectively. The ADC in patients with GS pathology graded low-risk, intermediate-risk and high-risk prostate cancer was (0.95 ± 0.11), (0.75 ± 0.12) and (0.61 ± 0.13) × 10 -3 mm 2/s, and the maximum tumor diameter was (1.27 ± 0.45), (2.17 ± 0.54) and (2.86 ± 0.63) cm. With the increase of the GS pathological grade, the ADC decreased, the maximum tumor diameter increased, and there were statistical differences ( F = 20.519 and 20.396, P<0.01). Spearman correlation analysis result showed that GS had negative correlation with ADC ( r = - 0.765, P<0.01), and positive correlation with the maximum tumor diameter ( r = 0.413, P<0.01). Conclusions:The diagnostic efficiency of mpMRI PI-RADS 2 for prostate cancer is relatively higher. ADC is negatively correlated with GS pathological grade, and the maximum tumor diameter is positively correlated with GS pathological grade, which provides a basis for preoperative diagnosis of prostate cancer.
