The association between inflammatory bowel disease and diabetes: a systematic review and Meta analysis
10.3760/cma.j.cn115455-20201211-01795
- VernacularTitle:炎症性肠病与糖尿病相关性的系统评价及Meta分析
- Author:
Xinyao WU
1
;
Qiao ZHANG
;
Zhangmin MENG
;
Huatian GAN
Author Information
1. 四川大学华西医院老年医学中心/干部医疗科，成都 610041
- Keywords:
Inflammatory bowel diseases, Diabetes mellitus;
Meta-analysis
- From:
Chinese Journal of Postgraduates of Medicine
2021;44(8):748-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between inflammatory bowel disease (IBD) and diabetes mellitus.Methods:The database of PubMed, EMBASE and Cochrane were searched by computer, and the related studies on the relationship between IBD and diabetes were collected. The retrieval time was from the database establishment to November 2, 2019. The heterogeneity analysis was conducted by Cochran Q test and I2 value. The relative risk ( RR) and 95% confidence interval ( CI) were used as the research indexes to conduct Meta analysis. Sensitivity analysis and publication bias test were also carried out. Results:Twelve observational studies were included in the study, and 216 024 IBD patients were included. Meta analysis showed that there was a significant correlation between IBD and diabetes ( RR = 1.27, 95% CI 1.09 - 1.49), and the risk of diabetes in IBD patients was 1.27 times higher than that of the general population. The results of subgroup analysis showed that: compared with the general population, the risk of type 2 diabetes mellitus (T2DM) in patients with ulcerative colitis (UC) increased ( RR = 1.44, 95% CI 1.25 -1.66), while the risk of type 1 diabetes mellitus (T1DM) had no significant difference. Compared with the general population, the risk of T1DM and T2DM in patients with Crohn′s disease (CD) both increased (T1DM: RR = 1.34, 95% CI 1.05 - 1.71; T2DM: RR = 1.44, 95% CI 1.01 - 2.07). Conclusions:There is a relationship between IBD and diabetes mellitus, and the risk of diabetes is increased in IBD patients.
