Analysis of the relationship between Helicobacter pylori cytotoxin-associated gene A, Helicobacter pylori isolate vacuole-forming toxin gene A and gastric cancer occurrence and clinicopathological factors
10.3760/cma.j.cn115455-20200710-00867
- VernacularTitle:幽门螺旋杆菌细胞毒素相关基因A、幽门螺旋杆菌分离株空泡形成毒素基因A与胃癌发生及临床病理因素的关系分析
- Author:
Haipeng YANG
1
;
Weimin HAO
;
Honglin XIA
Author Information
1. 安徽医科大学附属宿州医院（安徽省宿州市立医院）检验科 234000
- Keywords:
Helicobacter pylori;
Stomach neoplasms;
Cytotoxin-related gene A;
Isolate vacuolar toxin gene A;
Prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2021;44(8):709-714
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between Helicobacter pylori(HP) cytotoxin-associated gene A (HP-CagA), HP isolate vacuole-forming toxin gene A (HP-VacA) and gastric cancer occurrence and clinical pathological factors.Methods:Eighty-eight patients with gastric cancer from January 2018 to January 2020 in Suzhou Hospital Affiliated of Anhui Medical University was selected as the observation group, 80 patients with benign gastric lesions during the same period was selected as the benign control group, and 80 healthy patients was selected as the healthy control group. The clinical data, HP-CagA, HP-VacA positive expression rates of the three groups were compared, the risk factors of gastric cancer were analyzed, and the relationship between HP-CagA, HP-VacA and gastric cancer clinicopathological factors were evaluated.Results:Family history of gastric cancer, high-salt diet, preference for hot food, decreased pepsinogen (PG)Ⅰ/PGⅡ, combined with fatty liver, increased triglyceride, total cholesterol and low density lipoprotein cholesterin, smoking and depression were risk factors of gastric cancer ( P<0.05). The positive rate of HP-CagA, HP-VacA in the observation group were higher than those in the benign control group and the healthy control group: 82.93%(73/88) vs. 62.50%(50/80) and 26.25%(21/80), 30.68%(27/88) vs. 7.50%(6/80) and 0, the differences were statistically significant ( P<0.05). The positive of HP-CagA and HP-VacA had correlation with age, pathological type, and degree of differentiation of gastric cancer ( P<0.05). The 1-year survival rate of HP-CagA and HP-VacA positive patients was lower than that of negative patients by Kaplan-Meier analysis ( P<0.05). Conclusions:The positive of HP-CagA and HP-VacA in HP infections are closely related togastric cancer. Strengthening the treatment of HP infection patients with positive HP-CagA and HP-VacA has important clinical value and social significance for cutting off the early stage of gastric cancer and improving prognosis.
