Insights into immune mechanisms of ocular graft-versus-host disease

VernacularTitle:眼部移植物抗宿主病免疫机制的研究进展
Author: Yuan QIU ¹ ; Jing HONG
Author Information

1. 北京大学第三医院眼科　100191
Keywords: Ocular graft-versus-host disease; Cytokine; Tears; Biomarker
From: Chinese Journal of Experimental Ophthalmology 2021;39(11):1017-1020
CountryChina
Language:Chinese
Abstract: Ocular graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HSCT). However, the diagnostic criteria for ocular GVHD are controversial and mainly based on clinical experience.Objective and reliable diagnostic parameters for this disease are limited.As a result, most patients can not get early diagnosis and effective management.Tear cytokine profile analysis is a safe, convenient and noninvasive examination which reflects immune mechanisms of systemic and ocular diseases.Levels of certain cytokines in tear can serve as specific biomarkers of GVHD and thus have the potential to act as accurate diagnostic and prognostic tools.In this article, the current status of ocular GVHD diagnosis was summarized, the role of cytokines in immune mechanism and diagnosis of ocular GVHD were reviewed.