Specialized proresolving lipid mediators and eye diseases
10.3760/cma.j.cn115989-20200607-00402
- VernacularTitle:促炎症消退介质与眼部疾病
- Author:
Yingting ZHU
1
;
Yiqing LI
;
Yehong ZHUO
Author Information
1. 中山大学中山眼科中心 眼科学国家重点实验室，广州 510060
- Keywords:
Specialized proresolving lipid mediators;
Cornea;
Dry eye;
Uveitis;
Retina;
Glaucoma
- From:
Chinese Journal of Experimental Ophthalmology
2021;39(7):649-654
- CountryChina
- Language:Chinese
-
Abstract:
Novel endogenous lipid-mediated molecules including lipoxins, resolvins, protectins, and maresin families are discovered recently and are collectively called specialized proresolving lipid mediators (SPMs). SPMs have the potential to promote the resolution of inflammation, the elimination of pathogen, and the restoration of homeostasis.Meanwhile, SPMs also have the function of apoptosis inhibition, wound healing, and neuroprotection.SPMs play an important role in the treatment of many eye diseases, such as corneal inflammatory diseases, dry eye, uveitis, retinal and choroidal neovascularization diseases, etc.In this article, the mechanisms involving the role of SPMs in the occurrence and progress of eye diseases were reviewed to provide a general new basis for the future development of new ophthalmic drugs.
