Risk factors of necrotizing enterocolitis after surgery for intestinal atresia
10.3760/cma.j.issn.2096-2932.2021.05.004
- VernacularTitle:肠闭锁术后坏死性小肠结肠炎危险因素分析
- Author:
Yan TIAN
1
;
Junjian LYU
;
Qiuming HE
;
Wei ZHONG
;
Bo XIA
;
Jiale CHEN
;
Weiyi CHEN
;
Tulian LIN
;
Xiaoli XIE
;
Weitao ZHONG
;
Yanfeng PENG
Author Information
1. 广州医科大学附属广州市妇女儿童医疗中心出生缺陷疾病研究所省重点实验室和新生儿外科重症监护室 510630
- Keywords:
Enterocolitis,necrotizing;
Intestinal atresia;
Risk factors
- From:Chinese Journal of Neonatology
2021;36(5):15-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors of necrotizing enterocolitis (NEC) after surgery for intestinal atresia.Method:From August 2013 to June 2020, children with intestinal atresia receiving surgery in our hospital were retrospectively reviewed. The patients were assigned into NEC group and non-NEC group according to the occurrence of postoperative NEC. Demographic data and clinical characteristics were summarized and the risk factors for postoperative NEC were analyzed using Logistic regression analysis method.Result:A total of 96 infants were enrolled and NEC occurred in 13 patients (13.5%) after surgery for intestinal atresia. Compared with the non-NEC group, the NEC group were diagnosed of intestinal atresia [4.0(1.5,6.0)d vs. 1.4(0,2.0)d, P<0.001] and received surgery [4.8(2.0,7.0)d vs. 3.1(1.0,4.0)d, P=0.034] at later ages. The incidences of complex intestinal atresia [76.9%(10/13) vs. 44.6%(37/83), P=0.030] and blood transfusion [46.2%(6/13) vs. 13.3%(11/83), P=0.007] in the NEC group were higher than the non-NEC group. Logistic regression analysis showed that the age of initial diagnosis of intestinal atresia ( OR=3.346, 95% CI 1.493~7.500, P=0.003), complex intestinal atresia ( OR=9.052, 95% CI 1.119~73.209, P=0.039) and blood transfusion ( OR=6.835, 95% CI 1.399~33.380, P=0.018) were independent risk factors for postoperative NEC. Conclusion:Patients with delayed diagnosis of intestinal atresia, complex intestinal atresia and blood transfusion within 48 hours after surgery should be monitored for the occurrence of postoperative NEC.
