Metastatic Large Cell Neuroendocrine Carcinoma of the Lung Mimicking a Merkel Cell Carcinoma.
10.5021/ad.2002.14.2.121
- Author:
Jong Seo LEE
;
Won Soon CHUNG
;
Dong Hyun KIM
;
Jong Seo LEE
;
Soo Chan KIM
- Publication Type:Case Report
- Keywords:
Large cell neuroendocrine carcinoma;
Cutaneous metastasis
- MeSH:
Brain;
Carcinoma, Merkel Cell*;
Carcinoma, Neuroendocrine*;
Carcinoma, Squamous Cell;
Drug Therapy;
Follow-Up Studies;
Humans;
Keratin-20;
Lung*;
Microscopy;
Neoplasm Metastasis;
Prognosis;
Skin;
Tomography, X-Ray Computed
- From:Annals of Dermatology
2002;14(2):121-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Large cell neuroendocrine carcinoma (LCNEC) of the lung is a newly recognized entity of pulmonary neuroendocrine carcinoma. Histologically, it is very difficult to differentiate LCNEC from other pulmonary carcinomas and the prognosis is significantly poor. The cutaneous metastasis of LCNEC of the lung shares some features with Merkel cell carcinoma of the skin in light microscopy and yet it is negatively stained with cytokeratin 20. We report a case of cutaneous metastasis of LCNEC of the lung, previously misdiagnosed as squamous cell carcinoma. Our patient showed a poor response to the chemotherapy and also revealed a brain metastasis on follow-up brain CT scan.
