Effect of SMOF lipid on parenteral nutrition-associated cholestasis and other complications in premature infants
10.3760/cma.j.issn.1673-4912.2021.10.013
- VernacularTitle:多种油脂肪乳对早产儿肠外营养相关性胆汁淤积等并发症的影响
- Author:
Di YIN
1
;
Huating ZHANG
;
Na LI
;
Yunlin SHEN
;
Cheng CAI
;
Xiaohui GONG
;
Gang QIU
;
Yong HU
Author Information
1. 上海市儿童医院 上海交通大学附属儿童医院新生儿科 200062
- Keywords:
Fat emulsions;
Parenteral nutrition-associated cholestasis;
Parenteral nutrition;
Premature infants
- From:
Chinese Pediatric Emergency Medicine
2021;28(10):906-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effect of SMOF lipids composed of soybean oil, medium chain triglycerides, olive oil, and fish oil with medium-long chain mixed fat emulsions(Lipofundin) on parenteral nutrition-associated cholestasis(PNAC) in premature infants.Methods:Clinical data were collected from premature infants hospitalized in the neonatal intensive care unit of Shanghai Children′s Hospital from January 2018 to December 2019 with gestational age ≤34 weeks, birth weight ≤2 000 g, and duration of parenteral nutrition ≥14 days.They were devided into SMOF lipid group and Lipofundin group, and the incidence of PNAC, neonatal necrotizing enterocolitis(NEC), bronchopulmonary dysplasia(BPD), retinopathy of prematurity(ROP), periventricular-intraventricular hemorrhage(PVH-IVH), late-onset sepsis and liver function were compared between two groups.Results:The incidence of PNAC in the SMOF lipid group was significantly lower than that in Lipofundin group( P=0.042). The average level of ALT and AST in SMOF lipid group were markedly lower than those in Lipofundin group( P<0.05). The time to reach full enteral feeding of SMOF lipid group was shorter than that of Lipofundin group( P=0.005). There was no significant difference in the incidence of NEC, BPD, ROP, PVH-IVH, and late-onset sepsis between two groups( P>0.05). Conclusion:Compared with lipofundin, SMOF lipid can reduce the incidence of PNAC in premature infants, and has no significant effect on the incidence of NEC, BPD, ROP, PVH-IVH and late-onset sepsis.
