Clinical analysis of hyperphosphatemia in children with steroid-sensitive nephrotic syndrome
10.3760/cma.j.issn.1673-4912.2021.10.005
- VernacularTitle:儿童激素敏感型肾病综合征合并高磷血症临床分析
- Author:
Qian LI
1
;
Lichun YU
;
Jing WANG
;
Chunli LUAN
;
Yuan CHEN
;
Shuzhen SUN
Author Information
1. 山东第一医科大学附属省立医院小儿肾脏风湿免疫科，济南 250021
- Keywords:
Nephrotic syndrome;
Hyperphosphatemia;
Children
- From:
Chinese Pediatric Emergency Medicine
2021;28(10):864-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between hyperphosphatemia and steroid-sensitive nephrotic syndrome(SSNS)in children.Methods:A retrospective study was carried out in 61 children with SSNS at Department of Paediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2017 to December 2018.The changes of serum phosphorus levels during the active and remission stages were observed, and the correlation between serum phosphorus level and serum albumin, blood lipid, renal function, blood calcium, blood phosphorus, urine protein and other indicators were analyzed.Results:Serum phosphorus level of 61 children with SSNS was 1.79(1.65-1.91)mmol/L in the active phase of the disease, of which 33 patients(54.1%)had hyperphosphatemia, while serum phosphorus level was 1.64(1.46-1.79)mmol/L after the complete remission, and 15(24.6%)patients had hyperphosphatemia.Serum phosphorus level was positively correlated with ratio of urine protein/creatinine, serum lipoprotein A and calcium-phosphorus product( r=0.239, P<0.05; r=0.188, P<0.05; r=0.623, P<0.05), and negatively correlated with levels of serum albumin and serum calcium( r=-0.201, P<0.05; r=-0.195, P<0.05). Conclusion:The morbidity of hyperphosphatemia in children with SSNS is quite high during the active stage of the disease.The disorder of blood phosphorus significantly improve with remission of the disease.
