Research progress on AMPK/mTOR signaling pathway involved in immunometabolic regulation in sepsis
10.3760/cma.j.issn.1673-4912.2021.09.014
- VernacularTitle:AMPK-mTOR信号通路调控脓毒症免疫代谢的研究进展
- Author:
Xiaomeng TANG
1
;
Chunxia WANG
;
Yucai ZHANG
Author Information
1. 上海交通大学附属儿童医院重症医学科 上海交通大学儿科危重病研究所 上海交通大学医学院儿童感染免疫与重症医学研究院 200062
- Keywords:
AMP-activated protein kinase;
Mammalian target of rapamycin;
Metabolic reprogramming;
Immunoregulation;
Sepsis
- From:
Chinese Pediatric Emergency Medicine
2021;28(9):810-813
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence, development and prognosis of sepsis are closely related to immune regulation.Immunometabolism has been the research hotspot of immune intervention in sepsis in recent years.AMP-activated protein kinase(AMPK)and mammalian target of rapamycin(mTOR)are star molecules involved in metabolic regulation.As an important way of immunometabolic regulation in sepsis, AMPK-mTOR is involved in the process of chemotaxis of neutrophils, the polarization of macrophages, the development and differentiation of natural killer cells and dendritic cells, and the development and functional regulation of T cells.This article reviewed the research progress of AMPK-mTOR signaling pathway on regulating metabolic reprogramming in immune cells, which contributes to immunoregulation in sepsis.
