Risk factors for mixed infections and clinical characteristics in children with severe adenovirus pneumonia
10.3760/cma.j.issn.1673-4912.2021.09.003
- VernacularTitle:儿童重症腺病毒肺炎的临床特征及混合感染的高危因素分析
- Author:
Jiaotian HUANG
1
;
Xiulan LU
;
Yimin ZHU
;
Haipeng YAN
;
Xinping ZHANG
;
Zhenghui XIAO
;
Zhenya YAO
;
Desheng ZHU
;
Jun QIU
Author Information
1. 湖南省儿童医院重症医学科，长沙 410007
- Keywords:
Children;
Severe adenovirus pneumonia;
Clinical features;
Mixed infection
- From:
Chinese Pediatric Emergency Medicine
2021;28(9):756-762
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summary the mixed infection as well as clinical characteristics and analyze the risk factors for mixed infection of severe adenovirus pneumonia(SAP) in children.Methods:The clinical data of 114 children with SAP were retrospectively analyzed.Multivariate Logistic regression analysis was performed to assess the risk factors for mixed infection.Results:The incidence age was from 6 months to 2 years(62.5%). High fever(94.7%), cough(98.2%), dyspnea(86.8%) and lethargy(95.6%) were the main symptoms.Laboratory examination showed that children with SAP were prone to increased white blood cell count, C-reactive protein, procalcitonin, aspartate aminotransferase, alanine aminotransferase and CK-MB, as well as decreased proportion of CD3 + , CD4 + , CD8 + , CD4 + /CD8 + and NK cells.The main complications intrapulmonary organ were respiratory failure(80.7%). The main complications extrapulmonary organ were circulatory complications (55.3%). SAP was easily combined with other pathogenic infections.Streptococcus pneumoniae(22.9%)was the most common bacterial pathogen.Respiratory syncytial virus(10.0%)were the most common virus, in addition, mycoplasma pneumoniae(17.1%) was also common.Multivariable Logistic regression analysis showed that the decreasing ratio of CD4 + /CD8 + and NK cells, congenital heart disease and congenital airway dysplasia were the independent risk factors for mixed infection of SAP in children( P<0.05). Conclusion:The SAP patients could easily suffer from mixed infection and high fatality rate.Immune dysregulation is the important risk factors for mixed infection of SAP in children.So immunoregulatory treatment is very important.
