Three cases of Pulmonary Epithelioid Hemangioendothelioma.
- Author:
Seung Hyun LEE
1
;
Chang Gyun SEO
;
Sun Hyo PARK
;
Kyung Chan KIM
;
Min Soo KIM
;
Seung Beom HAN
;
Kun Young KWON
;
Young June JEON
Author Information
- Publication Type:Case Report
- Keywords: Pulmonary epithelioid hemangioendothelioma; Benign; Malignant
- MeSH: Female; Humans
- From:Tuberculosis and Respiratory Diseases 2002;53(1):56-65
- CountryRepublic of Korea
- Language:Korean
- Abstract: A pulmonary epithelioid hemangioendothelioma (PEH) is a rare tumor with a vascular origin. A PEH can arise in many organ systems, such as the lung, liver, bone and soft tissues. It is a borderline malignancy but the clinical course is usually benign. In this report, we describe three cases of PEH. Case 1, a 61-year-old man, had nonspecific chest discomfort and the chest X-ray showed a solitary lung nodule. This nodule was diagnosed by an open lung biopsy. The pathologic findings including abundant necrosis, mitosis and hyperchromatic and pleomorphic nuclei, indicated a malignancy. The electron microscopic study showed Weibel-Palade bodies and the immunohistochemical stain for CD31 showed a positive reaction in the tumor cells, and linear staining along the vascular lumina. Case 2, a 34-year-old man, was admitted for an evaluation of multiple small nodules, incidentally detected a screening chest X-ray. The nodules were diagnosed by a immunohistochemical stain for the factor VIII-related antigen. Case 3, a 34-year-old woman, complained of left pleuritic chest pain. A simple chest film and the chest CT scan revealed multiple bilateral nodules and a left pleural effusion. An immunohistochemical stain for the factor VIII-related antigen was used to diagnose the nodules. Forth-one months after the diagnosis, she died of pulmonary insufficiency.
