The effect of neonatal with very severely hyperbilirubinemia treated by plasma exchange
10.3760/cma.j.issn.1673-4912.2021.07.013
- VernacularTitle:血浆置换治疗新生儿极重度高胆红素血症疗效分析
- Author:
Xiaojing TANG
1
;
Xuefeng YANG
;
Jiahao TIAN
;
Jianping LIU
;
Min WANG
;
Yi WANG
Author Information
1. 西安交通大学附属儿童医院新生儿重症医学科 710003
- Keywords:
Plasma exchange;
Hyperbilirubinemia, neonate;
Exchange transfusion therapy
- From:
Chinese Pediatric Emergency Medicine
2021;28(7):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effectiveness and safety of plasma exchange in the treatment of neonatal extremely severe hyperbilirubinemia.Methods:A retrospective analysis was performed on the data of 18 cases, who were all newborns with extremely severe hyperbilirubinemia and treated with plasma exchange in the NICU at Xi ′an Children′s Hospital from April 2019 to December 2019.The changes of serum total bilirubin, indirect bilirubin, albumin, white blood cells, red blood cells, platelets, hematocrit, hemoglobin, serum sodium, serum potassium, serum calcium, blood glucose, blood coagulation and mean arterial pressure were compared before and after plasma exchange.Results:A total of 18 eligible children were included.The peak value of total bilirubin was (571.2±113.3) μmol/L before treatment, and the value after treatment was (235.8±66.7) μmol/L, whose difference was statistically significant ( P<0.05). The exchange rate of bilirubin was (58.5±8.4)%.There were no statistically significant differences in the changes of white blood cells, platelets, hemoglobin, hematocrit, serum sodium, serum potassium, serum chloride, serum calcium, serum glucose, and albumin before and after plasma exchange (all P>0.05). There were no allergic reactions, hypotension, plasma separator or pipeline coagulation and other adverse reactions during plasma exchange. Conclusion:Plasma exchange therapy can remove serum bilirubin quickly, effectively and safely, and may be a new treatment for neonatal hyperbilirubinemia.
