Prevention of Hypokalemia before Induction of Anesthesia by Clonidine or Midazolam.
10.4097/kjae.1998.34.5.920
- Author:
Hyun Sung CHO
1
;
Jeong Jin LEE
;
Sang Min LEE
;
Ik Soo CHUNG
;
You Hong KIM
;
Duck Hwan CHOI
;
Byung Seop SHIN
Author Information
1. Department of Anesthesiology, College of Medicine, Sung Kyun Kwan University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Electrolyte: hypokalemia;
Premedication: Clonidine;
Midazolam
- MeSH:
Anesthesia*;
Anxiety;
Central Nervous System;
Clonidine*;
Humans;
Hypokalemia*;
Midazolam*;
Outpatients;
Premedication
- From:Korean Journal of Anesthesiology
1998;34(5):920-924
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Selective 2-agonists cause decrease in serum K+ concentration. Midazolam is an anxiolytic, sedative, and amnestic drug. Premedication of midazolam prevents increase of catecholamine with anxiety. Clonidine, alpha 2-adrenergic receptor agonist, supresses sympathetic outflow from central nervous system. So we can expect that premedication of clonidine or midazolam will prevent hypokalemia before induction of anesthesia. METHODS: Twenty two patients received 300 mcg clonidine per oral, 22 patients 0.05 mg/kg midazolan IM and 22 patients had no premedication. We measured serum K+ level at out-patient Department (T1), at 11:00 P.M. of the day before surgery (T2) and immediately before induction of anesthesia (T3). RESULTS: Serum K+ levels at T2 decreased compared to serum K+ level at T1 in all groups. Serum K+ levels T3 decreased compared to serum K+ level at T2 in control and midazolam groups but clonidine group did not decrease in serum K+ level. CONCLUSIONS: We can not prevent decrease of serum K+ level with premedication of midazolam but we can prevent decrease of serum K+ level with premedication of clonidine. So premedication of clonidine is more effective than midazolam in prevention of hypokalemia before induction of anesthesia.
