Effect of DHEA Administration before, during and after Dexamethasone Treatment on Body Weight and Mass of TypeI, II Muscles in Rats.
10.4040/jkan.2002.32.5.727
- Author:
Myoung Ae CHOE
1
;
Gi Soo SHIN
;
Gyeong Ju AN
;
Eun Ju LEE
Author Information
1. College of Nursing, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
DHEA;
dexamethasone;
body weight;
muscle mass;
TypeI,II muscle
- MeSH:
Animals;
Body Weight*;
Dehydroepiandrosterone*;
Dexamethasone*;
Muscles*;
Rats*;
Rats, Wistar
- From:
Journal of Korean Academy of Nursing
2002;32(5):727-734
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was to determine the effect of DHEA administration before, during, and after dexamethasone treatment on body weight and TypeI,II muscle weight of rat receiving dexamethasone treatment. METHOD: Wistar rats were divided into 6 groups: control(C), dexamethasone(D), DHEA administration for 3days after dexamethasone treatment for 7days(7D+3DH), dexamethasone treatment for 7days after DHEA administration for 3days(3DH+7D), DHEA administration during dexamethasone treatment for 4days after dexamethasone treatment for 3days(3D+4DDH), DHEA administration during dexamethasone treatment for 7days(7DDH). Dexamethasone was injected by subcutaneously daily at a dose of 5mg/kg. DHEA was orally administered daily at a dose of 5mg/kg for 7 days. Soleus(TypeI) muscle, and both plantaris and gastro- cnemius(TypeII) muscles were dissected on the 7th day of experiment. RESULT: Body weight of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. Body weight of 7D+3DH group decreased significantly compared with that of 7D group, 7DDH group, 3DH+7D group and 3D+4DDH group. Muscle weight of both plantaris and gastro- cnemius tended to decrease compared with that of 7D group. Muscle weight of 7DDH group, 3D+4DDH group and 3DH+7D group increased significantly compared with that of 7D+3DH group. Muscle weight of gastrocnemius of both 3DH+7D group and 3D+4DDH group increased significantly compared with that of 7D group. CONCLUSION: Based on these results, it can be suggested that DHEA administration before and during dexamethasone treatment can increase both body weight and mass of atrophied TypeII muscle induced by dexa- methasone treatment.
