Analysis of long-term health related-quality of life in pediatric patients with acute leukemia at post-hemato-poietic stem cell transplantation
10.3760/cma.j.cn101070-20200818-01366
- VernacularTitle:急性白血病造血干细胞移植后患儿长期健康相关生存质量分析
- Author:
Yan YAN
1
;
Yanhui LUO
;
Siyu CAI
;
Ying CHANG
;
Yuchen ZHOU
;
Peiyi YANG
;
Ruixin WANG
;
Xuan ZHOU
Author Information
1. 首都医科大学附属北京儿童医院血液肿瘤中心，北京 100045
- Keywords:
Hematopoietic stem cell transplantation;
Long-term quality of life;
Influence factor;
Acute leukemia;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(23):1791-1795
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the long-term health-related quality of life (QOL) in pediatric patients with acute leukemia after hematopoietic stem cell transplantation (HSCT) and to analyze potential influence factors.Methods:Patients with acute leukemia aging 8-18 years who received HSCT in the Hematology Oncology Center of Beijing Children′s Hospital from June 2009 to June 2012 with more than 80 months survival postoperatively were recruited.All of them were subjected to a short-term QOL survey in 2013.PedsQL? Transplantation Module 3.0 in Chinese mandarin version was completed.QOL data and influence factors were analyzed.Results:Forty-one patients completed the questionnaires, involving 32 males and 9 females with the mean age of(14.29±2.72) years.The mean scores of overall long-term QOL after HSCT were above 75 (total scores: 100), which was above the average.The age, disease status before transplantation, donor sources, post-transplant complications and the parental education level were the influential factors for the long-term QOL in pediatric patients with acute leukemia at post-HSCT, which could affect a certain dimension in QOL.Conclusions:The overall long-term QOL of pediatric patients with acute leukemia who survived for more than 80 months at post-HSCT is acceptable, which is significantly better than the short-term QOL after 4 months of HSCT.The age, disease status before transplantation, donor sources, post-transplant complications and the education level of parents could affect a certain dimension of QOL.
