Case report of Langerhans cell histiocytosis in 2 neonates
10.3760/cma.j.cn101070-20200616-01002
- VernacularTitle:新生儿朗格汉斯细胞组织细胞增生症2例
- Author:
Lu QIN
1
;
Feizhou ZHANG
;
Tongyu YANG
;
Wanli FENG
;
Lanfang TANG
Author Information
1. 浙江大学医学院附属儿童医院呼吸科，杭州 310051
- Keywords:
Histiocytosis;
Langerhans cell;
Infant, newborn;
Clinical feature
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(21):1659-1661
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the clinical data of 2 neonates with Langerhans cell histiocytosis (LCH). The rashes appeared in both cases shortly after birth.Case 1 had both rashes and neonatal sepsis, and no other tissues and organs were involved.After anti-infective treatment, the rashes gradually disappeared.Case 2 had secondary pneumonia, abnormal coagulation function and gastrointestinal bleeding.Both cases were positive for CD1a and S-100 by immunohistochemical staining of skin biopsy, and they were diagnosed as multi system-LCH.The early diagnosis of LCH is particularly important.The detection methods of skin or lymph node biopsy like immunohistochemistry, need to be performed as early as possible.Because the course of the disease is not clear, a close monitoring and follow-up are needed.
