Research progress of deficiency of interleukin-36 receptor antagonist and cutaneous sterile pustulosis
10.3760/cma.j.cn101070-20210204-00159
- VernacularTitle:白细胞介素36受体拮抗剂缺陷与皮肤无菌性脓疱病研究进展
- Author:
Yachen WANG
1
;
Zhenhua ZHANG
;
Zigang XU
Author Information
1. 国家医学儿童中心，首都医科大学附属北京儿童医院皮肤科，北京 100045
- Keywords:
Pustulosis, aseptic;
Skin;
IL36 RN gene
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(20):1598-1600
- CountryChina
- Language:Chinese
-
Abstract:
Cutaneous sterile pustulosis is categorized as a non-infectious and non-follicular impetigo, with a low prevalence and difficulty in the treatment.Deficiency of interleukin(IL)-36 receptor antagonist (DITRA) is an auto inflammatory disease featured by the decreased interleukin-36 receptor antagonist (IL-36Ra) activity caused by IL36 RN mutation.Functional or structural defects of IL-36Ra increase the secretion of inflammatory and pro-inflammatory factors by keratinocytes, macrophages and dendritic cells.Upregulation of IL-36 receptor agonists induce type 17 helper T lymphocytes to secrete IL-17, which is essential for the onset of multiple subtypes of aseptic pustulosis.Research on the relationship between DITRA and cutaneous sterile pustulosis is important for developing targeted therapies.
