Application of transient elastography in assessing hepatic fibrosis in pediatric chronic liver disease
10.3760/cma.j.cn101070-20200806-01305
- VernacularTitle:应用瞬时弹性成像评估慢性肝病儿童肝纤维化程度
- Author:
Yanyan YAN
1
;
Yuchuan LI
;
Jiayan FENG
;
Yi ZHANG
;
Jianshe WANG
;
Xinbao XIE
Author Information
1. 复旦大学附属儿科医院肝病研究中心，上海 201102
- Keywords:
Transient elastography;
Hepatic fibrosis;
Chronic liver disease;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(19):1475-1479
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the transient elastography (TE) in assessing hepatic fibrosis in pediatric chronic liver disease.Methods:Children with chronic liver disease who were both examined with TE and percutaneous transhepatic puncture for grading Scheuer scores in the Children′s Hospital of Fudan University from January 2017 to September 2017 were recruited.Ordinal Logistic regression analysis was used to analyze the interfering factors for hepatic fibrosis.Receiver operating characteristic (ROC) curves were plotted to acquire the optimal cut-off value and to calculate the area under the curve (AUC). Results:Thirty-eight children were enrolled finally, including 28 boys and 10 girls with the mean age of 7.4 years old (1.1-16.0 years). The success rate of detecting hepatic fibrosis was 85%.Ordinal Logistic regression analysis discovered that only the value of liver stiffness measured by TE was correlated with the grade of hepatic fibrosis ( β=0.055, P<0.001). TE was effective to differentiate hepatic fibrosis[
