Effect of reproduction on maternal and infant outcomes in female patients with systemic lupus erythematosus
10.3760/cma.j.cn101070-20200803-01288
- VernacularTitle:系统性红斑狼疮女性患者再分娩对母婴结局的影响
- Author:
Shuming SHAO
1
;
Yimin ZHANG
;
Xiaorui ZHANG
;
Jie LIU
;
Chaomei ZENG
Author Information
1. 北京大学人民医院儿科 100044
- Keywords:
Systemic lupus erythematosus;
Reproduction;
Maternal and infant outcomes
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(18):1403-1406
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of reproduction on maternal and infant outcomes in female patients with systemic lupus erythematosus (SLE).Methods:Clinical data of SLE patients complicated with pregnancy admitted in the Peking University People′s Hospital from July 2015 to December 2019 were analyzed retrospectively.According to the history of live birth, SLE patients complicated with pregnancy were divided into primiparity group (94 cases) and reproduction group (32 cases). Maternal and infant outcomes of the 2 groups were analyzed.Results:A total of 126 SLE patients complicated with pregnancy were included in the present study.The proportion of using immunosuppressants was significantly lower in reproduction group than that of primiparity group [3 cases (9.38%) vs.27 cases (28.72%)] ( χ2=4.927, P=0.026). Complications like lupus nephritis, thyroid disease and postpartum hemorrhage significantly increased in the reproduction group (all P<0.05), and the adverse neonatal outcomes like preterm infants, low birth weight infants and small for gestational age infants in the reproduction group were lower than those in primiparity group, but no significant differences were detected(all P>0.05). There were no significant diffe-rences in the results of the first blood routine examination of newborns and the incidence of neonatal pathological jaundice between the 2 groups (all P>0.05). Conclusions:For SLE patients complicated with reproductive pregnancy, although the incidence of some pregnancy complications increases, the incidence of adverse neonatal outcomes decreases.In addition, reducing the use of immunosuppressants may have positive implications on neonatal outcomes.
