Advances on animal experimental study of mesenchymal stem cell extracellular vesicles in the treatment of bronchopulmonary dysplasia

VernacularTitle:间充质干细胞囊泡治疗支气管肺发育不良的动物实验研究进展
Author: Mi YAN ¹ ; Qubei LI
Author Information

1. 重庆医科大学附属儿童医院儿科研究所，儿童发育疾病研究教育部重点实验室，国家儿童健康与疾病临床医学研究中心，儿童发育重大疾病国家国际科技合作基地，儿科学重庆市重点实验室，重庆市，400014
Keywords: Mesenchymal stem cell; Extracellular vesicles; Exosomes; Bronchopulmonary dysplasia; Child
From: Chinese Journal of Applied Clinical Pediatrics 2021;36(16):1277-1280
CountryChina
Language:Chinese
Abstract: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that commonly occurs in preterm infants requiring mechanical ventilation and oxygen therapy.BPD usually has a poor long-term prognosis due to the lack of effective prevention and treatment method currently, which is one of the medical problems to be solved urgently.Many animal experiments indicated that mesenchymal stem cell extracellular vesicles (MSC-EVs) can replace mesenchymal stem cells as an effective treatment strategy for BPD, which has great application prospect.At present, the use of MSC-EVs has gradually deepened into the molecular mechanism and made new progress.In order to explore the value of MSC-EVs in the treatment of BPD, the recent advances on the mechanism of MSC-EVs in the treatment of BPD are investigated.