Changes of the renin-angiotensin-aldosterone system in children with orthostatic intolerance and their significance
10.3760/cma.j.cn101070-20200622-01041
- VernacularTitle:直立不耐受患儿肾素-血管紧张素-醛固酮系统的变化及意义
- Author:
Xiangyu DONG
1
;
Yao XIAO
Author Information
1. 兰州大学第二医院小儿心血管科 730030
- Keywords:
Renin-angiotensin-aldosterone system;
Orthostatic intolerance;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(13):978-982
- CountryChina
- Language:Chinese
-
Abstract:
Orthostatic intolerance (OI) is the most common type of autonomic mediated syncope in children.Children with OI tend to show intolerance to the postural changes and long-term standing, thus often presenting with such clinical symptoms as dizziness, headache, blackness, and even sudden fainting.Although there is no organic lesion from OI, it can still exert serious impacts on the mental health of children.Therefore, it is of great significance to provide active and effective treatment for children with OI.There is some understanding of OI, but it is still unclear about its pathogenesis, which is believed to be related to dysautonomia and abnormal neurohumoral regulation.In this paper, the focus would be placed on the changes of renin-angiotensin-aldosterone system (RAAS) in neurohumoral regulation and their significance, and an exploration would be performed on the impacts of related treatment on RAAS in children with OI.
