Diagnosis progress in component-resolved diagnostics of food allergy
10.3760/cma.j.cn101070-20210517-00542
- VernacularTitle:食物过敏的变应原组分诊断进展
- Author:
Zixi WANG
1
;
Jinlyu SUN
;
Lianglu WANG
Author Information
1. 北京协和医院变态反应科，中国医学科学院北京协和医学院，国家皮肤与免疫疾病临床医学中心，疑难重症及罕见病国家重点实验室，过敏性疾病精准诊疗北京市重点实验室，北京 100730
- Keywords:
Food allergy;
Molecular allergy diagnostics;
Allergen component;
Component-resolved diagnostics
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(12):897-901
- CountryChina
- Language:Chinese
-
Abstract:
IgE-mediated food allergy is a common health problem worldwide, and the incidence of food allergy in China is also increasing gradually in the past decades.However, the traditional diagnostic measurements for food allergen specific IgE (sIgE) are based on the in- vivo or in- vitro tests of the intact allergen extracts, with low specificity and sensitivity, as well as limited diagnostic information.Therefore, the clinical diagnosis of food allergies often requires an oral food challenge test, which increases the suffering and risk of patients.Along with the development of component-resolved diagnostics (CRD) of food allergy, the sIgE against a single allergenic component can be measured quantitatively, thus generating the concept of " CRD" , which makes food allergy diagnosis more accurate and helps people distinguish cross allergens, determine the severity of the disease and the risk of severe allergic reactions, and predict the efficacy of immunotherapy.Besides, the diagnostic accuracy would be enhanced significantly and the reliance on oral food challenge tests would be reduced.In this review, the new progress in the diagnosis of common food allergen components would be summarized, and the advantages of CRD would be discussed.
