Effects of early endoscopic therapy on inflammatory factors and efficacy in elderly patients with acute biliary pancreatitis
10.3760/cma.j.cn.115807-20210218-00050
- VernacularTitle:早期内镜治疗老年急性胆源性胰腺炎对炎症因子及临床疗效的影响
- Author:
Dengqiu ZHAO
1
;
Yiming CHEN
;
Yefeng WU
;
Yunjie WANG
;
Yu ZHANG
Author Information
1. 上海健康医学院附属周浦医院肝胆外科 201318
- Keywords:
Acute biliary pancreatitis;
Aged;
Endoscopic therapy;
Infiammatory factors
- From:
Chinese Journal of Endocrine Surgery
2021;15(5):514-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the inflammatory factors effects of early endoscopic therapy for elderly patients with acute biliary pancreatitis (ABP) and its clinical efficacys.Methods:206 elderly patients with ABP admitted from Jan. 2010 to Dec. 2019 were divided into observation group (102 cases) and the control group (104 cases) according to treatment method. The observation group received endoscopic retrograde cholangiopancreatography (ERCP) , endoscopic sphincterotomy (EST) and endoscopic naso-biliary drainage (ENBD) , while the control group received conventional treatment. Clinical symptoms, changes of inflammatory factors, complications and prognosis were observed in each group.Results:CRP, SAA, IL-6, IL-8 and TNF-a after treatment were significantly lowered than those before treatment ( P<0.05) . In addition, the levels of CRP, SAA, IL-6, IL-8 and TNF-a in the observation group were significantly lower than those in the control group ( P<0.05) . The time to abdominal pain extinction, time to fever cessation, hospital stay in observation group were (3.92±1.54) , (3.63±1.41) , and (14.35±2.46) d, significantly less than those in the control group [ (5.81±1.72) , (5.45±2.13) , (19.37±3.12) d, P<0.05]. APACHE Ⅱ score of the observation group was (10.02±2.67) point after treatment, significantly lower than that in the control group [ (12.35±3.62) point, t=4.42, P<0.05]. The incidence of complications in the observation group was 10.78% after treatment, significantly lower than that in the control group [ (24.03%) , χ2=6.27, P< 0.05]. The mortality in the observation group was 1.96%, lower than 4.81% in the control group, with no statistical significance. Conclusion:Early endoscopic therapy is safe and highly effective for elderly patients with ABP, with the advantages of shorter hospital stay, quicker subsided inflammation, and lower incidence of complications.
