The value of peripheral blood component of T cells and neutrophil to lymphocyte ratio in thyroid cancer coexisted with Hashimoto’s thyroiditis
10.3760/cma.j.cn.115807-20191009-00188
- VernacularTitle:血清T细胞亚群及中性粒细胞淋巴细胞比值在甲状腺癌合并桥本氏甲状腺炎中的临床价值
- Author:
Cuizhong WANG
1
;
Tong SHEN
;
Yichen ZHONG
;
Dexuan CHEN
;
Zhaoqun MA
;
Haijian SUN
Author Information
1. 南京中医药大学附属医院普外科 210029
- Keywords:
Thyroid carcinoma;
Hashimoto’s thyroiditis;
Neutrophil to lymphocyte ratio (NLR)
- From:
Chinese Journal of Endocrine Surgery
2021;15(4):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate clincal value of preoperative peripheral blood CD4/CD8 and neutrophil to lymphocyte ratio (NLR) in papillary thyroid carcinoma (PTC) coexisted with Hashimoto’s thyroiditis (HT) .Methods:Clinicopathological data of 202 patients diagnosed as PTC treated with operation from Jul.2016 to Jun.2019 were retrospectively analyzed. They were divided into Treatment Group including 94 PTC coexisted with HT and Control Group including 108 thyroid cancer according to the postoperateive pathology report. CD4+ and CD8+ subsets in peripheral blood were analyzed by flowcytometer and blood counts were measured before surgery.Results:There was no significant difference in gender, tumor size, number of lesions or lymph node metastasis between the two goups. In comparison with Control Group, median age was lower (39.5 vs 50.5, P=0.001) and CD4/CD8 raito (1.9731.973 Cvs 1.24141973 CD P=0.001) was higher in Treatment group. There was a higher proportion of bilateral lobe thyroidectomy in Treatment Group (40/94 vs 26/108, P=0.005) . A multivariate model analysis identified CD4/CD8 raito as independent risk factor for incidence of PTC coexisted with HT [ OR=0.035, 95% CI (0.009-0.093) , P=0.001]. The NLR level of thyroid cancer patients was correlated with lateral lymph node metastasis negatively (correlation coefficients=-0.286, P=0.045) . Conclusions:PTC might have some connection with HT mediated by body inmune status. Preoperative NLR level is correlated with lateral lymph node metastasis.
