Effects of propofol and sevoflurane on post-traumatic stress disorder after emergency surgery in trauma patients
10.3760/cma.j.issn.1671-0282.2021.11.012
- VernacularTitle:七氟烷和丙泊酚对急诊外伤术后创伤后应激障碍发病的影响
- Author:
Youjia YU
1
;
Xinchun ZHANG
;
Yan LI
;
Shigang QIAO
;
Yangzi ZHU
;
Lichao FANG
;
Xuefei XU
Author Information
1. 苏州市相城人民医院麻醉科 215131
- Keywords:
Trauma;
Post-traumatic stress disorder;
Propofol;
Sevoflurane;
Emergency surgery
- From:
Chinese Journal of Emergency Medicine
2021;30(11):1349-1352
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of propofol and sevoflurane on post-traumatic stress disorder (PTSD) after emergency surgery in trauma patients.Methods:A total of 160 trauma patients undergoing emergency surgery under general anesthesia were randomly divided into the propofol group and the sevoflurane group. The perioperative clinical data of the two groups were collected. The incidence of PTSD was evaluated by PCL-5 score one month after the operation in the two groups. The relevance of the injury time and PCL-5 score was assessed by Spearman correlation analysis. Logistic regression analysis was used to analyze the risk factors of PTSD.Results:The incidence of PTSD in the propofol group was significantly higher than that in the sevoflurane group at postoperative 1 month (24.0% vs 10.8%, P=0.034). The injury time was negatively correlated with PCL-5 score in the propofol group ( r=0.229, P<0.01). There was no correlation between the injury time and the PCL-5 score in the sevoflurane group ( r=0.001, P=0.804). Logistic regression analysis showed that the use of propofol was an independent risk factor for PTSD ( P=0.004). Conclusions:Sevoflurane anesthesia is more effective than propofol anesthesia in reducing the occurrence of PTSD in emergency surgery for trauma patients.
