The Correlation between GDF15 and sudden death
10.3760/cma.j.issn.1671-0282.2021.06.009
- VernacularTitle:生长分化因子15与猝死的相关性研究
- Author:
Shangqing CHANG
1
;
Yunjing SHENG
;
Guoxin HAN
;
Shuoshuo LI
;
Haiyan ZHU
Author Information
1. 急诊医学科，中国人民解放军总医院海南医院，海南省三亚 572013
- Keywords:
Sudden death;
Growth differentiation factor15;
Cardiac markers;
Coronary heart disease;
Acute myocardial infarction;
Troponin t;
Creatine Kinase;
Creatine Ki
- From:
Chinese Journal of Emergency Medicine
2021;30(6):689-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the early warning and prediction value of GDF15 for sudden death patients.Methods:From January to December 2018, 49 patients with sudden death who were treated in the Emergency Department of the First Clinical Center of PLA General Hospital were included in the case group, and 46 healthy physical examiners in the Physical Examination Center of the Hospital were randomly selected as the control group. The general situation, comparison of myocardial markers and analysis of the basic data of the case group were carried out, so as to evaluate the early warning value of each myocardial marker in sudden death.Results:Patients aged 40-49 years old accounted the highest proportion among sudden death cases, reaching 26.54%. Sudden death under 60 years old accounted for 59.19%, and the ratio of male to female was 3.83:1. There were significant differences between the case group and the control group in CK-MB [(41.35±98.38) vs. (3.13±2.17), P=0.009], CK [(2652.82±6845.66) vs. (102.73±47.93), P=0.012], and GDF15 [(549.80±809.79) vs. (115.70±167.42), P=0.001]. At the same time, the AUC value of GDF15 was 0.816, which has the highest diagnostic value for sudden death. And CK-MB, CK and GDF15 had no correlation with age. Conclusions:GDF15, as a biological marker, has a good early warning function in sudden death.
