Oral lichen planus induced by long-term use of antimicrobials for recurrent aphthous ulcer:A case report and literature review
10.11817/j.issn.1672-7347.2021.200817
- VernacularTitle:长期使用抗菌药物治疗复发性口腔溃疡引起口腔扁平苔藓1例并文献复习
- Author:
Wenjie LI
1
,
2
,
3
;
Xuyang GAO
;
Yuetong WANG
;
Yiqi XU
;
Xin ZHANG
;
Jun CHEN
Author Information
1. 中南大学湘雅口腔医学院湘雅口腔医院,长沙410008
2. 粉末冶金国家重点实验室,长沙410083
3. 轻质高强结构材料国家级重点实验室,长沙410083
- Keywords:
oral lichen planus;
Candida infection;
misuse of antimicrobial;
stewardship
- From:
Journal of Central South University(Medical Sciences)
2021;46(6):666-672
- CountryChina
- Language:Chinese
-
Abstract:
The precise etiology of oral lichen planus(OLP)is still unclear,but the existing evidence suggests that drug intake,virus infection,fungal infection,psychological disorders,and immunodeficiency are closely associated with the pathogenesis of OLP.We report a case of OLP accompanied with candidiasis induced by long-term use of antimicrobials for recurrent aphthous ulcer(RAU)and update the literature,to discuss the possible association between OLP and misuse of antimicrobials,and to inform general dentists and pharmacists the importance for practice with optimal antimicrobial stewardship.In this case,a 42-year-old man presented to Xiangya Stomatological Hospital with white reticular patterns spreading in the oral cavity for almost 1 year.He was diagnosed with OLP via histopathological examination.He had a 5-year history of RAU which occurred every 1-2 months,and he was given antimicrobials ingested or injected whenever the ulcers came up.Satisfactory treatment results were obtained by stopping the abuse of antimicrobials and local antifungal therapy.Meanwhile,the exacerbation and alleviation of OLP was closely related to the administration of antimicrobials.Combined with literature review,antimicrobial might contribute to the development of OLP by inducing candidiasis,a common side-effect of misuse of antimicrobials.Considering the seriousness of antimicrobial resistance and opportunistic infection,dentists should prescribe antimicrobials judiciously according to guidelines and evidence-based indications.Appropriate prescribing of antimicrobials is a professional responsibility to all dentists.
