Study on the optimization of the preparation technic and pharmacological activity of Chuanxiong Rhizoma
10.3760/cma.j.cn115398-20200722-00240
- VernacularTitle:川芎真空蒸汽润药制备工艺优化及其抗炎镇痛活性研究
- Author:
Zhaoyu CHEN
1
;
Li ZHUANG
;
Kun ZHENG
;
Guangming HAN
;
Zongmin ZHANG
Author Information
1. 山东省日照市中医医院药剂科 276800
- Keywords:
Chuanxiong Rhizoma;
Assay (TCD);
Central composite design;
Response surface method;
Anti-inflammation and analgesia
- From:
International Journal of Traditional Chinese Medicine
2021;43(12):1234-1239
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the preparation technic of Chuanxiong Rhizoma with vacuum steam method, and to investigate the anti-inflammatory and analgesic activity of Chuanxiong Rhizoma decoction pieces with Central Composite Design-Response Surface Method. Methods:Taking the content of ferulic acid as the evaluation index and the moistening temperature, moistening time and vacuum time as the observation indexes, the moistening technic of Chuanxiong Rhizoma was optimized by Response Surface Method, and selected the optimized plan. The anti-inflammatory and analgesic activities of Chuanxiong Rhizoma were investigated by auricle swelling induced by xylene and writhing induced by glacial acetic acid. Results:The optimum vacuum moistening technic was that the softening temperature was 80 ℃, the softening time was 50 min and the vacuum time was 45 min. The content of ferulic acid in Chuanxiong Rhizoma produced by this technic is highand could decreased the times of wrinkle reaction induced by acetic acid in mice, prolonged the latent period, and obviously or partially inhibitied the ear swelling degree induced byxylene in rats. Conclusions:The Response Surface Method technic of Chuanxiong Rhizoma is easy to operate with high accuracy. The vacuum steam treatment was more obvious than traditional technology group. It provides reference for the subsequent production of Chuanxiong Rhizoma decoction pieces and have the certain value for its promotion and application.
