Mechanism analysis of Sanhan-Qushi-Wenjing-Tongluo formula treating psoas fasciitis based on biological information technology
10.3760/cma.j.cn115398-20200702-00029
- VernacularTitle:基于网络药理学探讨散寒祛湿温经通络复方治疗腰肌筋膜炎机制
- Author:
Yinping WANG
1
;
Peng FAN
;
Yu NIU
;
Fenghong GUO
;
Ting ZHAO
;
Tao LAN
;
Hailong WANG
;
Chao LIU
Author Information
1. 河北省秦皇岛市中医医院康复科 066000
- Keywords:
Fasciitis;
Sanhan-Qushi-Wenjing-Tongluo Formula;
Network pharmacology;
Molecular mechanisms of pharmacological action (TCD)
- From:
International Journal of Traditional Chinese Medicine
2021;43(11):1124-1130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effective chemical constituents and target genes of the Sanhan-Qushi-Wenjing-Tongluo formula through the method of network pharmacology, and to further analyze the mechanism of treatoffing psoas fasciitis. Methods:The TCMSP database was used to search and screen the chemical active substances of Sanhan-Qushi-Wenjing-Tongluo formula and its target proteins acting on the human body. At the same time, the GeneCards database platform was used to predict the target of disease and the active ingredient-target network was constructed. Construct a PPI network through the STRING database, search for PPI core genes, and then perform GO enrichment analysis and KEGG enrichment analysis to find the signal pathways involved and construct a target-path network. Results:Through screening, a total of 23 key chemical components and 25 common target proteins was obtained in Sanhan-Qushi-Wenjing-Tongluo formula treating psoas fasciitis; gene analysis of enrichment analysis results include antibiotic response, cyclin-dependent proteins kinase holoenzyme complex, cytokine receptor binding, etc. Kyoto Encyclopedia of Genes and Genomes enrichment analysis results include AGE-RAGE signaling pathway, measles, endocrine resistance, inflammatory bowel disease, etc; the target genes gained which have a higher degree of matching with the above mentioned pathways include IL6, JUN, IL1B, CDK4, CCND1. Conclusion:Sanhan-Qushi-Wenjing-Tongluo formula could treat psoas fasciitis by regulating the target genes such as IL6, JUN, IL1B, CDK4 and CCND1.
