Prescription rule of Chinese medicine patents for heart failure
10.3760/cma.j.cn115398-20200512-00091
- VernacularTitle:治疗心力衰竭的中药复方专利组方规律研究
- Author:
Jian HE
1
;
Xiaochang MA
;
Qing WANG
;
Linlin CAI
Author Information
1. 中国中医科学院广安门医院药物临床试验机构办公室，北京 100053
- Keywords:
Heart failure;
Traditional Chinese Medicine Inheritance Support System;
Chinese herbal patents;
Prescription rule
- From:
International Journal of Traditional Chinese Medicine
2021;43(10):1023-1028
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the medication regularity and prescription rule of Chinese herbal medicine in the treatment of cardiac failure.Methods:The China Patent Publication Notice of the State Intellectual Property Office (http://epub.sipo.gov.cn/) was rearched and retrievedfor Chinese herbal medicine for the treatment of heart failure. The Traditional Chinese Medicine (TCM) inheritance support system (V 2.5) was used to input the prescription information and establish the database. The association rules, mutual information method, entropy clustering of complex systems and other data mining methods were used for commonly used drugs, combination rule and new prescription of core group.Results:A total of 101 prescriptions were included, involving 316 drugs. The frequency of commonly used drugs were Astragali Radix (59.41%), Poria (41.58%), Salviae Miltiorrhizae Radix et Rhizoma (40.59%), Descurainiae Semen Lepidii Semen (34.65%), Aconiti Lateralis Radix Praeparata (33.66%), and the medicinal properties were mainly warm, and the sweet taste. The main flavors weresweet, bitterness, and pungency, and the main sources of meridians belonged to liver, spleen, heart, lungs and kidneys. The most commonly used drug combinations contribute to supplement Qi, invigorate blood circulation and stasis, warm Yang, remove moisture. There were 12 core drug groups and 6 new prescriptions for heart failure. Conclusions:Analysis on formulas for heart failure shows that the prescriptions focus on supplementing qi and activating blood circulation, warming Yang reducing dampness, invigorating spleen, and nourishing Yin, dispel turbid, solid Yang. It can provide reference for clinical treatment to improve curative effect and standardize prescription medication.
