Mechanism research of Maxing-Ersan Decoction in the treatment of COPD based on network pharmacology
10.3760/cma.j.cn115398-20200421-00221
- VernacularTitle:基于网络药理学探讨麻杏二三汤治疗慢性阻塞性肺疾病作用机制
- Author:
Sijie LI
1
;
Zhiwan WANG
;
Yulong XU
Author Information
1. 河南省濮阳市中医医院肺病科 457000
- Keywords:
Pulmonary disease, chronic obstructive;
Network pharmacology;
Ma Xing Er San Tang;
Molecular mechanisms of pharmacological action (TCD)
- From:
International Journal of Traditional Chinese Medicine
2021;43(10):1011-1017
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the targets and signal pathways of Maxing-Ersan Decoction in the treatment of COPD by using network pharmacology, and to reveal the mechanism of intervention of multiple targets and multiple pathways of Maxing-Ersan Decoction in the treatment of COPD. Methods:The active ingredients and corresponding targets of Maxing-Ersan Decoction were screened with the help of TCMSP database, and the targets related to COPD disease were screened with GeneCards database. The STRING database was used for protein-protein interaction (PPI) network analysis. By using Cytoscape to build compound target network and PPI network; by using Draw Venn Diagram website to draw a Venn diagram, and using R software to perform gene ontology (GO) functional enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG). Results:A total of 101 active ingredients were obtained, with 250 corresponding targets, including 214 targets related to COPD. Through GO and KEGG enrichment analysis, all together 48 signal pathways related to the main components of Maxing-Ersan Decoction were screened out. Conclusion:Based on the network pharmacological analysis, the effective chemical components of Maxing-Ersan Decoction were found, and it was found that Maxing-Ersan Decoction may act on COPD through multiple targets and multiple pathways such as inflammation and immune regulation.
