Optimization of the matrix formulation of Erhuang analgesic gels by central composite design-response surface methodology
10.3760/cma.j.cn115398-20200916-00149
- VernacularTitle:星点设计-效应面法优化二黄止痛凝胶剂基质处方研究
- Author:
Xu ZHOU
1
;
He TU
;
Mingquan WU
;
Wei PENG
;
Liyang ZHU
;
Limei LIU
Author Information
1. 四川省骨科医院中药研究室，成都 610041
- Keywords:
Technology improving (TCD);
Central composite design-response surface methodology;
Erhuang analgesic gel;
Matrix formulation;
In vitro release
- From:
International Journal of Traditional Chinese Medicine
2021;43(10):1000-1005
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the matrix formulation of Erhuang analgesic gels. Methods:Central composite design-response surface methodology was adopted to optimize the best formulation of Erhuang analgesic gels by using carbomer 940, triethanolamine and glycerine as independent variables, the appearance, stability, viscosity and in vitro release of berberine hydrochloride as comprehensive evaluation indices. Results:The fitting regressing equation was Y= 82.25 + 4.95 A+ 5.19 B + 1.41 C+ 1.51 AB + 0.904 0 AC- 0.531 9 BC- 2.92 A2-1.80 B2-0.182 1 C2. P value of the model was less than 0.000 1, and the correlation coefficient r value was 0.977. The optimal formulation of Erhuang analgesic gels consisted of 1.84% carbomer 940, 1.30 times triethanolamine of carbomer 940 and 13.99 grams of glycerine. The average comprehensive scores of three verification experiments was 88.56, and the deviations from the predicted values were 2.93%, 2.85% and 1.55%. Conclusion:The formulation process by central composite design-response surface methodology was stable and the formulation of Erhuang analgesic gels has been optimized.
