Clinical study of Guben-Tiaoping Decoction in improving the success rate of inhaled corticosteroid stepwise treatment in asthma
10.3760/cma.j.cn115398-20201026-00150
- VernacularTitle:固本调平汤辅助提高支气管哮喘吸入糖皮质激素降阶梯治疗成功率临床研究
- Author:
Wei GAO
1
;
Weiping WU
;
Huiping SU
;
Di LUO
;
Yangfan LI
;
Fang SU
;
Minhua CHEN
;
Yu LI
Author Information
1. 北京市朝阳区中医医院内科 100020
- Keywords:
Asthma;
Glucocorticoids;
Administration, inhalation;
Stepwise treatment;
Guben-Tiaoping Decoction;
Traditional Chinese Medicine therapy
- From:
International Journal of Traditional Chinese Medicine
2021;43(10):954-959
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of combined use of Guben-Tiaoping Decoction on the success rate of stepwise treatment and life quality of asthma patients. Methods:A total of 76 patients with asthma in remission stage who were using ICS were divided into treatment group (38 cases) and control group(38 cases) according to random number table. Both groups were treated with ICS reduction based on the 2017 Gina Protocol. The treatment group was treated with Guben-Tiaoping Decoction for 12 weeks. The number of patients who were able to successfully complete the stepwise treatment after the end of the trial was calculated, the relevant indexes of Asthma Control Test (ACT), TCM Syndrome score, St. George’s respiratory questionnaire (SGRQ) and lung function were collected before and after treatment. Result:After 12 weeks’ treatment, the success rate of stepwise was 89.5% (34/38) in the treatment group and 78.9% (30/38) in the control group ( χ2=14.862, P=0.001). Meanwhile, the ACT score of the treatment group were better than those in the control group (Daytime symptoms t=-3.860, P=0.001, Dyspnea t=-2.007, P=0.40, Night waking t=-2.732, P=0.009, Reliever needed for symptoms t=-2.262, P=0.031, Control situation t=-6.994, P=0.001, Total Score t=-9.562, P=0.001). The score of TCM Syndrome in the treatment group was significantly lower than that of the control group ( P=0.001); PEF in treatment group [(6.92 ± 1.71) L vs. (5.84 ± 1.22) L; t=-2.880, P=0.005] was significantly better than that of the control group. Conclusion:Guben-Tiaoping Decoction is helpful to improve the success rate of ICS stepwise treatment and the life quality of patients.
