Mechanisms analysis of the reinforcing effect of Epimedii Folium on kidney in the treatment of polycystic ovarian syndrome with network pharmacology
10.3760/cma.j.cn115398-20200619-00214
- VernacularTitle:基于网络药理学探讨淫羊藿补肾作用对多囊卵巢综合征的影响
- Author:
Yidan ZHANG
1
;
Tingting MAI
;
Zhexin NI
;
Jie DING
;
Chaoqin YU
;
Zailong CAI
Author Information
1. 海军军医大学基础医学院2018级中医八年制，上海 200433
- Keywords:
Epimedii Folium;
Polycystic ovary syndrome;
Reinforcing kidney;
Network pharmacology;
Molecular mechanisms of pharmacological action (TCD)
- From:
International Journal of Traditional Chinese Medicine
2021;43(8):796-802
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study by using the method of network pharmacology to screen the active constituent and related targets of Epimedii Folium aims to explore the mechanisms of the reinforcing effect of Epimedii Folium on kidney in the treatment of PCOS. Methods:By retrieving data from TCMSP datebase, screened out the active constituent of Epimedii Folium and the information of the targets corresponding to each active constituent; by using the gene database of NCBI, translated the information of the targets into gene names; by retrieving data from GeneCards datebase, extracted the genes related to PCOS; related targets of Epimedii Folium in the treatment of PCOS were obtained by Venn tool; by using Cytoscape 3.7.2 software, constructed a network diagram of Epimedii Folium-active constituents-targets-PCOS; by using STRING database, constructed the protein interaction network; then carried out GO enrichment analysis of related targets by Geneontology database and carried out pathway enrichment analysis of related targets by KEGG database. Results:There were 23 active constituents of Epimedii Folium and 132 related targets treating PCOS. The Epimedii Folium could play the reinforcing effect on kidney mainly by regulating the biological processes like steroid hormone receptor activity, as well as KEGG pathways such as Estrogen signaling pathway, GnRH signaling pathway, GnRH secretion, HIF-1 signaling pathway and VEGF signaling pathway in treating PCOS. Conclusion:From the perspective of network pharmacology, this study preliminarily analyzed the related targets and pathways of reinforcing effect on kidney of Epimedii folium in the treatment of PCOS, providing reference for further experiments and application inclinics.
