Research advances of m 6A methylation modification in digestive system neoplasms

VernacularTitle:m 6A甲基化修饰在消化系统肿瘤中的研究进展
Author: Peipei LIU ¹ ; Mengxue YANG ; Xuebing YAN
Author Information

1. 扬州大学附属医院肿瘤科　225000
Keywords: Methylation; Digestive system neoplasms; Biomarker; N 6-methyladenosine
From: Journal of International Oncology 2021;48(11):688-692
CountryChina
Language:Chinese
Abstract: N 6-methyladenosine (m 6A) methylation modification is defined as the methylation at the N 6 position of adenosine. This dynamic process is regulated by writer, eraser and reader. Accumulating evidence indicates that m 6A methylation modification is involved in the initiation and development of various digestive system neoplasms including proliferation, invasion, metastasis and chemoresistance. A further understanding about the role of m 6A methylation modification in digestive system neoplasms will benefit the development of a novel precise diagnostic and therapeutic strategy and finally improve the overall prognosis of patients.