Role of cancer-associated fibroblasts in breast cancer
10.3760/cma.j.cn371439-20201208-00120
- VernacularTitle:肿瘤相关成纤维细胞在乳腺癌中的作用
- Author:
Ailing WANG
1
;
Ximei NIU
;
Guofu HUANG
;
Xiaoling LENG
Author Information
1. 新疆医科大学第五附属医院肿瘤科，乌鲁木齐 830000
- Keywords:
Breast neoplasms;
Cancer-associated fibroblasts;
Tumor microenvironment
- From:
Journal of International Oncology
2021;48(10):614-617
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between breast cancer cells and the tumor microenvironment plays a vital role in the occurrence and development of breast cancer. Cancer-associated fibroblasts are heterogeneous stromal cells that are abundant in the tumor microenvironment. They participate in tumor angiogenesis, treatment resistance and distant metastasis by secreting a variety of cytokines, growth factors and chemokines. It has great potential as a biomarker for targeted therapy and clinical prognosis of breast cancer, and it can also provide new ideas for adjuvant treatment of breast cancer.
