Research progress of brain injuries in patients with small cell lung cancer caused by prophylactic cranial irradiation

VernacularTitle:预防性全脑照射引起小细胞肺癌患者脑损伤的研究进展
Author: Hong′e ZHANG ¹ ; Qinghua ZHOU ; Jiewei LIU ; Shuang DAI ; Jie ZHOU
Author Information

1. 四川大学华西医院肺癌中心，成都　610041
Keywords: Small cell lung carcinoma; Brain injuries; Cognitive dysfunction; Prophylactic cranial irradiation
From: Journal of International Oncology 2021;48(9):568-571
CountryChina
Language:Chinese
Abstract: Small cell lung cancer (SCLC), as a pathological type with high malignancy, presents a high risk of early brain metastasis. Prophylactic cranial irradiation (PCI) can reduce the risk of brain metastasis in patients with SCLC, however, the incidence of brain structural and functional damage caused by PCI is high, and their clinical symptoms are not typical. The existing treatment methods can relieve some clinical symptoms, but can not effectively reverse the process of brain injury, which reduces the survival benefit of patients. In-depth understanding the mechanisms of PCI neurotoxicity and exploring effective strategies for ptevention and treatment are of great value in improving prognosis of SCLC.