Role of substrate stiffness in the treatment of malignant tumor
10.3760/cma.j.cn371439-20201122-00108
- VernacularTitle:基底刚度在恶性肿瘤治疗中的作用
- Author:
Bo′er DENG
1
;
Weimin KONG
Author Information
1. 首都医科大学附属北京妇产医院妇瘤科 100006
- Keywords:
Neoplasms;
Chemoradiotherapy;
Molecular targeted therapy;
Substrate stiffness
- From:
Journal of International Oncology
2021;48(9):557-559
- CountryChina
- Language:Chinese
-
Abstract:
Substrate stiffness is one of the important mechanical parameters of extracellular matrix. Different substrate stiffness will affect the proliferation, movement and phenotype of tumor cells. It is found that the change of substrate stiffness is also related to the chemotherapy and radiotherapy sensitivity of tumor cells. Substrate stiffness can cause changes in the characteristics of tumor stem cells, which are related to the activation or inactivation of some signaling pathways, mainly involving ABCG2 protein and Akt/mTOR/Sox2 signaling pathway. Further study on the role of substrate stiffness in radiotherapy, chemotherapy and targeted therapy of malignant tumor is expected to provide basis for the clinical treatment of malignant tumor.
