Role of tumor microenvironment in tumor drug resistance

VernacularTitle:肿瘤微环境在肿瘤耐药中的作用
Author: Weida FU ¹ ; Mengjiao CHEN ; Guilong GUO ; Shurong ZHENG
Author Information

1. 温州医科大学附属第一医院乳腺外科　325000
Keywords: Tumor microenvironment; Drug resistance; Stromal cells; Acellular component
From: Journal of International Oncology 2021;48(9):553-556
CountryChina
Language:Chinese
Abstract: Tumor microenvironments (TMEs) are closely related to tumor resistance. TMEs are divided into cellular components and acellular components. The cellular components include tumor-associated macrophages, tumor-associated fibroblasts, mesenchymal stem cells, etc., which can enhance tumor resistance through recruitment and secretion of a variety of protective cytokines; acellular components such as extracellular matrix, hypoxia and acidification, etc., can mediate drug resistance by constructing physical barriers, affecting tumor cell growth and metabolism. Studying the mechanisms of TME-mediated drug resistance and reshaping TMEs can provide new strategies for anti-tumor therapy.