Mechanism and application of hypoxia affecting immunotherapy drug resistance

VernacularTitle:缺氧影响免疫治疗耐药的机制与应用
Author: Peiyao CHEN ¹ ; Junmei JIA
Author Information

1. 山西医科大学第一临床医学院，太原　030000
Keywords: Immunotherapy; Drug resistance, neoplasm; Hypoxia-inducible factor 1, alpha subunit; Immune checkpoint inhibitor
From: Journal of International Oncology 2021;48(8):489-493
CountryChina
Language:Chinese
Abstract: Immunotherapy is a new anti-tumor method. The application of immune checkpoint inhibitor greatly improves the survival benefit for patients, but the drug resistance of immunotherapy affects the efficacy. Therefore, it is very important to explore the mechanism of drug resistance and solve the problem of drug resis-tance in tumor immunotherapy. Hypoxia in tumor microenvironment is the key factor of immune drug resistance. Hypoxia can inhibit the immune cells function and lead to immune escape through various mechanisms. It can be the breakthrough for overcoming the immunotherapy drug resistance that blocking pathway of hypoxia to promote immune resistance. By reviewing the mechanism of immunotherapy drug resistance induced by hypoxia, it is helpful to explore the development prospect of hypoxia-inducible factor-1α (HIF-1α) related targeted drugs in clinical application for immunotherapy.