Role of LHPP in malignant tumor
10.3760/cma.j.cn371439-20200630-00080
- VernacularTitle:LHPP在恶性肿瘤中的作用
- Author:
Tiantian LI
1
;
Min CHEN
;
Yichen LIU
;
Jie PENG
;
Xiaofeng SHI
Author Information
1. 江苏大学附属医院血液科，镇江 212000
- Keywords:
Neoplasms;
Phosphatidylinositol 3-kinase;
Prognosis;
LHPP
- From:
Journal of International Oncology
2021;48(7):420-423
- CountryChina
- Language:Chinese
-
Abstract:
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a highly conserved histidine phosphatase from worms to humans in evolution. Recent studies have shown that LHPP, as a tumor suppressor, can inhibit the proliferation, growth and migration of the cells and promote apoptosis by participating in the regulation of various cell signaling pathways and protein phosphorylation. Therefore, the deeply study on the mechanism of LHPP is helpful to explore the best diagnostic markers and therapeutic targets for related tumors, which is essential for improving the prognosis of related tumors.
