CDX2 and gastrointestinal neoplasms
10.3760/cma.j.cn371439-20201118-00072
- VernacularTitle:CDX2与胃肠道肿瘤
- Author:
Xinyue JU
1
;
Chunmei HU
;
Yue ZHAO
;
Yan TANG
Author Information
1. 吉林大学第二医院肿瘤血液科，长春 130041
- Keywords:
CDX2 transcription factor;
Digestive system neoplasms;
Intestinal metaplasia
- From:
Journal of International Oncology
2021;48(6):374-376
- CountryChina
- Language:Chinese
-
Abstract:
Caudal type homeobox transcription factor 2 (CDX2) is an enteric-specific nuclear transcription factor, which is mainly expressed in the small intestine and colorectum and not expressed in normal gastric mucosa. CDX2 is involved in the occurrence, development, invasion and metastasis of gastrointestinal tumors, and its expression state is related to the clinicopathological characteristics and prognosis of patients with gastrointestinal tumors. It is expected to provide a new idea for the diagnosis and treatment of gastrointestinal tumors by further studying the mechanism of CDX2 involvement in tumor genesis and development and its relationship with clinicopathological features and prognosis.
