Research and application of liquid biopsy based on epigenetic markers in the diagnosis and treatment of solid tumors
10.3760/cma.j.cn371439-20200918-00068
- VernacularTitle:基于表观遗传标志的液体活检在实体瘤诊疗中的研究与应用
- Author:
Weitao ZHUANG
1
;
Guibin QIAO
Author Information
1. 广东省医学科学院 广东省人民医院胸外科，广州 510080
- Keywords:
Neoplasms;
Biomarkers, tumor;
Epigenomics;
Liquid biopsy
- From:
Journal of International Oncology
2021;48(6):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic changes are closely related to carcinogenesis, tumor progression and prognosis, which have a considerable potential in assisting the precision and minimally invasive management of cancers. The progress of detection techniques for DNA methylation, hydroxymethylation and histone modification has promoted the research works of liquid biopsy targeting epigenetic markers, and recently, important progress has been made in tumor location, early diagnosis, clinical staging, evaluation of treatment response, monitoring of recurrence and prognostic prediction of solid tumors.
