Role of P2X7 receptor in colon cancer progression
10.3760/cma.j.cn371439-20200903-00050
- VernacularTitle:P2X7受体在结肠癌进展中的作用
- Author:
Qianqian LI
1
;
Xiaodi ZHU
;
Ronglan ZHAO
;
Xiaoxiang PENG
Author Information
1. 潍坊医学院医学检验学院纳米医学技术研究所 潍坊医学院临床检验诊断学山东省 "十二五" 高校重点实验室 261053
- Keywords:
Receptors, purinergic P2X7;
Colonic neoplasms;
Adenosine triphosphate
- From:
Journal of International Oncology
2021;48(4):250-253
- CountryChina
- Language:Chinese
-
Abstract:
P2X7 receptor is an ion channel receptor with adenosine triphosphate (ATP) as its ligand, which is widely expressed in various immune cells and tissues. Activated P2X7 receptor is involved in a variety of physiological and pathological processes. P2X7 receptor is abnormally expressed in colon cancer, and plays a duel role of cancer-promoting and cancer-suppressing in colon cancer progression. When P2X7 receptor is activated by extracellular ATP, it can effectively inhibit proliferation and induce apoptosis of colon cancer cells through various mechanisms. In addition, P2X7 receptor can also promote the growth, invasion and metastasis of colon cancer. Understanding the activation of P2X7 receptor and its effect mechanism is of great significance for the treatment of colon cancer.
